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目的 :探讨氟碳微泡造影剂对肾 VX2肿瘤显影的增强效果及不同显像方式、造影剂量对造影效果的影响。方法 :10只新西兰兔 ,右肾植有 VX2肿瘤 ,共 2 8个结节。经外周静脉注射氟碳微泡造影剂 0 .0 5、 0 .1、 0 .2 ml/kg,分别用基波显像和二次谐波显像观察造影效果。结果 :造影使肾肿瘤的检出率明显增加 ,由造影前的 4/2 8提高到基波显像的 15 /2 8和谐波显像的 2 1/2 8。二次谐波显像造影效果优于基波显像 ,在 0 .1ml/kg造影时 ,肿瘤组织与肾皮质间的视频密度差值分别为 90 .6 0± 7.75 ,45 .0± 5 .95 ,差异显著 (P<0 .0 1) ,随造影剂量的增加造影效果增强。结论 :氟碳声学造影剂能提高超声对肾肿瘤的诊断 ,二次谐波显像优于基波显像 ,有剂量 -效应关系
Objective: To investigate the effect of fluorocarbon microvesicle contrast agent on the development of renal VX2 tumors and the effects of different imaging modalities and contrast dosages on the imaging. Methods: Ten New Zealand rabbits, the right kidney with VX2 tumor, a total of 28 nodules. Peripheral intravenous injection of fluorocarbon microvesicle contrast agents 0. 0 5, 0 .1, 0 .2 ml / kg, respectively, with fundamental imaging and second harmonic imaging were observed contrast effects. Results: The contrast enhanced the detection rate of renal tumors from 4/2 8 before contrast imaging to 15/2 8 for fundamental imaging and 2 1/2 8 for harmonic imaging. Harmonic imaging of second harmonic imaging was better than that of fundamental imaging. The difference of the video density between tumor tissue and renal cortex at 0. 1ml / kg angiography was 90.60 ± 7.75 and 45.0 ± 5 respectively. 95, the difference was significant (P <0. 01), with the increase of contrast agent imaging enhanced. Conclusion: Fluorocarbon contrast agent can improve the diagnosis of renal tumors by ultrasound, and the second harmonic imaging is better than the imaging of the fundamental wave with dose-effect