Objective:To investigate the antibacterial and antioxidant activities of hydroalcoholic extract of Scholia latifolia(S.latifolia) bark commonly used in South Africa traditional medicine for the treatment of various ailments.Methods:The antibacterial test and MIC was determined by using agar well diffusion and dilution methods respectively against eight strains of bacteria. The total phenol,proanthocyanidin and flavonoid contents of 5.latifolia were assessed using Standard methods.The antioxidant activity of the extract was evaluated using ferric reducing power and the free radical scavenging activity against 1.1-diphenyl-2-picrylhydrazyl(DPPH), 2.2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic-acid(ABTS),nitric oxide(NO),hydrogen peroxide(H_2O_2) and lipid oxidation(LO).Results:The antibacterial activity demonstrated an appreciable effect against all the gram positive bacteria at MIC between 0.016 and 10 mg/ml. while that of gram negative bacteria was above 10 mg/mL.The plant extract exhibited high concentration of proanthocyanidin[(300.00±0.10) mg CE/g].followed by flavonoid[(12.46±0.04 mg) TE/g]and phenol[(1 l.06±0.03) mg QE/g]contents.Similarly,the extract at 0.5 mg/mL scavenges DPPH.ABTS.H_2O_2.LO and NO by 87.55%.89.47%.77.15%.86.48%and 77.75%of the radicals respectively.The reducing power was also found to be concentration dependent Conclusions: Our data suggest that S.latifolia extract has antibacterial and antioxidants activity and thus could be used as alternative therapv against antibiotic resistance bacteria and to prevent man) radical related diseases. Objective: To investigate the antibacterial and antioxidant activities of hydroalcoholic extract of Scholar latifolia (S. latifolia) bark commonly used in South Africa traditional medicine for the treatment of various ailments. Methods: The antibacterial test and MIC was determined by using agar well diffusion and The total phenol, proanthocyanidin and flavonoid contents of 5. latifolia were assessed using Standard methods. antioxidant activity of the extract was evaluated using ferric reducing power and the free radical scavenging activity against 1.1-diphenyl- 2-picrylhydrazyl (DPPH), 2.2’-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), nitric oxide (NO), hydrogen peroxide (H_2O_2) and lipid oxidation (LO) .Results: The antibacterial activity demonstrated an appreciable effect against all the gram positive bacteria at MIC between 0.016 and 10 mg / ml. while that of gram negative bacteria was above 10 mg / mL. The plant extract ex hibited high concentration of proanthocyanidin [(300.00 ± 0.10) mg CE / g] .followed by flavonoid [(12.46 ± 0.04 mg) TE / g] and phenol [(1 1.06 ± 0.03) mg QE / g] contents.Similarly , the extract at 0.5 mg / mL scavenges DPPH.ABTS.H 2 O 2 .LO and NO by 87.55% .89.47% .77.15% .86.48% and 77.75% of theclutters.The reduced power was also found to be concentration dependent Conclusions: Our data suggest that S.latifolia extract has antibacterial and antioxidants activity and therefore could be used as alternative therapv against antibiotic resistance bacteria and to prevent man) radical related diseases.