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目的··:探讨丁螺环酮对海洛因依赖者在脱毒期间焦虑、心理渴求的疗效和副作用。方法··:在美沙酮脱毒时随机取美沙酮联合丁螺环酮与单独美沙酮治疗各70例进行为期10d的对比观察。采用Zung 自评焦虑量表 (SAS)和自拟的心理渴求评分表每日评定一次并记录不良反应情况。结果··:美沙酮联合丁螺环酮组较单独美沙酮组焦虑、心理渴求分值明显减少 ,两者差异非常显著 (P<0.01)。丁螺环酮的不良反应有头痛、胃肠道不适、兴奋等 ,但不影响治疗。结论·· :丁螺环酮可有效地减轻海洛因依赖者在脱毒期间的焦虑情绪、心理渴求和觅药行为的程度
Objective · ·: To investigate the efficacy and side effects of buspirone on heroin dependence during anxiety and psychological cravings. Methods · · ·: Methadone detoxification randomized methadone combined with buspirone and methadone alone treatment of 70 cases for a period of 10d comparative observation. Adopt Zung Self-Rating Anxiety Scale (SAS) and self-made psychological craving scale to evaluate once a day and record the adverse reactions. Results · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · - - - - - - - · · · · Buspirone adverse reactions have headache, gastrointestinal discomfort, excitement, etc., but does not affect the treatment. CONCLUSIONS: Buspirone can effectively reduce the degree of anxiety, psychological craving and drug seeking behavior of heroin addicts during detoxification