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本实验用小白鼠约氏疟原虫和斯氏按蚊系统,做了小白鼠对约氏疟原虫的重复感染实验和患鼠服氯喹后原虫感染能力的观察。结果表明,大部分小白鼠感染约氏疟原虫后能迅速产生保护性免疫力,由子孢子感染的24只小鼠服氯喹治愈后,再以子孢子重复感染,阳性的1只,占4.17%。由输血感染的26只小白鼠服氯喹治愈后,再以输血重复感染,阳性的3只,占11.5%,此结果显示,小白鼠以子孢子感染治愈后对于孢子的免疫力,远远超过输血感染的小白鼠。此外,约氏疟阳性小白鼠服氯喹后对斯氏按蚊感染的成功率明显低于正常阳性小鼠;服药后10h内对原虫感染能力的影响很小,20～24h后感染能力则明显下降。
In this experiment, mice with P. yoelii and Anopheles stephensi system were used in mice to do experiments on repeated infection of Plasmodium yoelii and the ability to infect chloroquine-resistant protozoa in mice. The results showed that most of the mice infected with Plasmodium yoelii can quickly produce protective immunity. The 24 mice infected by sporozoites were treated with chloroquine, then they were repeatedly infected with sporozoites. The positive rate was 4.17%. Twenty-six white mice infected with blood transfusion were treated with chloroquine and then repeatedly infected with blood transfusion. Three of them were positive, accounting for 11.5%. The results showed that immunity to spores of mice cured by sporozoites far exceeded blood transfusion Infected mice. In addition, the success rate of Clostridium Anopheles infection in chloroquine-resistant mice was significantly lower than that in normal-positive mice after taking chloroquine, while the infection ability to protozoa was little within 10h after taking chloroquine, and the infection ability decreased significantly after 20 ~ 24h .