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目的：研究依咪酯在脊髓水平有无镇痛作用．方法：采用鞘内给药方法观察依咪酯对大鼠足底皮下注入蜜蜂毒诱致持续性痛反应的抑制效应．结果：①鞘内插管术未引起运动障碍及其它毒性反应，对大鼠皮下注入蜜蜂毒（ＢＶ）诱致的１ｈ内缩足反应总次数鞘内插管组［（６８６．１７±５５．０１）次／ｈ，ｎ＝７］与单纯ＢＶ注入组［（６０２．７１±４７．７３）次／ｈ，ｎ＝６］比较无统计学差别（Ｐ＞０．０５）；②鞘内注射３个剂量的依咪酯对ＢＶ诱致的缩足反应具有剂量依赖性抑制作用．与鞘内注射脂肪乳组总缩足次数［（６３３．００±６９．５０）次／ｈ，ｎ＝６］比较，剂量４０μｇ组对大鼠缩足反应的抑制率为１０．３３％［（５６７．６０±５１．４９）次／ｈ，ｎ＝５］；剂量８０μｇ组抑制率为２９．９４％［（４４３．５７±６２．８７）次／ｈ，ｎ＝７］；剂量１２０μｇ组抑制率为４２．６４％［（３８３．１０±１２．８３）次／ｈ，ｎ＝５］，其中剂量８０μｇ和１２０μｇ组与鞘内注射脂肪乳组比较均有显著差异．结论：本研究证实鞘内依咪酯可抑制大鼠足底皮下注入蜜蜂毒诱致的痛反应，依咪酯在脊髓水平存在镇痛作用．
Objective: To study whether there is analgesic effect of imatinide at spinal level. Methods: The intrathecal administration method was used to observe the inhibitory effect of icimide on sustained pain response induced by bee venom injected subcutaneously into the plantar. Results: ① Intrathecal intubation did not cause dyskinesia and other toxic reactions, and the total number of contractions induced by subcutaneous bee venom (BV) induced within 1 hour of intrathecal intubation was (686.17 ± 55.01 ) Times / h, n = 7] had no statistical difference (P> 0.05) when compared with pure BV injection group [(602.71 ± 47.73) times / h, n = 6) A dose-dependent dose-dependent inhibition of BV induced contractile response. Compared with intrathecal fat-reducing group, the total contracting foot number [(633.00 ± 69.50) times / h, n = 6] 567.60 ± 51.49) times / h, n = 5]. The inhibitory rate of 80μg group was 29.94% [(443.57 ± 62.87) / h, n = 7] The rate was 42.64% [(383.10 ± 12.83) times / h, n = 5], and the dose of 80μg and 120μg group were significantly different from that of intrathecal fat emulsion group. Conclusion: This study demonstrates that intrathecal imidacloprid can inhibit the pain reaction induced by bee venom injected subcutaneously into the plantar foot in rats, and that there is analgesic effect at the spinal cord level of imatinide.