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本文研究了猪苓多糖对化疗药物顺铂增效作用及其毒性的影响。结果显示,不同剂量的猪苓多糖与顺铂伍用均能明显提高顺铂对小鼠移植肿瘤S180、Lewis及H22三种瘤株的抑瘤率,与单用顺铂相比,P<0.05~0.01;能拮抗顺铂所致小鼠白细胞减少、免疫器官萎缩、巨噬细胞吞噬功能降低等毒副反应,为临床联合用药提供了实验研究。
This paper studied the effect of Polyporus umbellatus polysaccharide on the synergistic effect and toxicity of cisplatin. The results showed that the use of different doses of Polyporus umbellatus polysaccharides and cisplatin can significantly increase the tumor inhibition rate of cisplatin on transplanted tumors S180, Lewis and H22 tumors in mice, compared with cisplatin alone, P<0 .05 ~ 0.01; can antagonize the cisplatin-induced mouse leukopenia, immune organ atrophy, macrophage phagocytosis and other toxic side effects, for the clinical combination of drugs provides experimental research.