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采用链菌素亲生物蛋白-过氧化酶（S-P）快速免疫组化法检测了49例NSCLC组织和49份配对淋巴结标本P53和nm23基因产物（NDPK／nm23）表达，结果显示：NSCLC组织P53蛋白表达阳性率为73．47％（36／49），nm23蛋白表达的阳性率为57．14％（28／49），两者均阳性者为51．02％（25／49），肺癌淋巴结转移灶，P53无一例阳性表达，而nm23表达为53．85％（14／26），表明两者在NSCLC的作用机理可能不同，结果提示：P53基因异常改变与肺癌的发生关系甚为密切，它的改变在肺癌可能是一个早发信号。nm23在肺癌淋巴结转移灶的高表达，提示其在肺癌发生、转移中可能起着不同的作用。
The expression of P53 and nm23 gene products (NDPK/nm23) in 49 NSCLC tissues and 49 matched lymph node specimens were detected by streptavidin-protonophile-peroxidase (SP) immunohistochemistry. The results showed that P53 protein was expressed in NSCLC tissues. The positive rate of expression was 73.47% (36/49). The positive rate of nm23 protein expression was 57.14% (28/49), and the positive rate of both was 51.02% (25/49). Lymph node metastasis was found in lung cancer. In the foci, there was no positive expression of P53, but nm23 expression was 53.85% (14/26), indicating that the mechanism of action of both may be different in NSCLC. The results suggest that abnormal changes in P53 gene are closely related to the occurrence of lung cancer. The change in lung cancer may be an early signal. The high expression of nm23 in lymph node metastases of lung cancer suggests that it may play a different role in the occurrence and metastasis of lung cancer.