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目的探讨阿奇霉素序贯疗法对于促进支原体肺炎患儿症状改善及安全性的临床效果分析。方法选取2015年2月-2016年8月在广东省妇幼保健院确诊患有支原体肺炎的100例患儿,以就诊号随机数字法将其分为阿奇霉素组及红霉素组,每组各50例。阿奇霉素组50例患儿进行静脉滴注阿奇霉素治疗,红霉素组50例患儿予以常规静脉滴注红霉素进行治疗。比较两组患儿治疗后的疗效、临床症状消失时间、住院时间和不良反应发生情况。结果患儿临床治疗总有效率阿奇霉素组为95.0%,显著高于红霉素组(55.0%);阿奇霉素组患者的啰音消失时间、咳嗽消失时间、发热消退时间,以及总住院时间均显著少于红霉素组;患儿不良反应发生率红霉素组(32%)明显高于阿奇霉素组(10%)。两组比较差异均具有统计学意义(P<0.05)。结论阿奇霉素序贯疗法治疗支原体肺炎,能够显著缓解患儿的临床症状,起效快,总住院时间缩短,不良反应发生率减少,值得临床推广。
Objective To investigate the clinical effect of sequential therapy of azithromycin on improving the symptoms and safety of children with mycoplasma pneumonia. Methods A total of 100 children with mycoplasmal pneumonia who were diagnosed with mycoplasmal pneumonia in Guangdong Provincial MCH from February 2015 to August 2016 were randomly divided into azithromycin group and erythromycin group with 50 example. 50 cases of azithromycin group were treated with intravenous azithromycin, 50 cases of erythromycin group were given routine intravenous infusion of erythromycin for treatment. The curative effect, the disappearance of clinical symptoms, the length of hospital stay and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of clinical treatment in children with azithromycin was 95.0%, significantly higher than that of erythromycin group (55.0%); patients with azithromycin disappeared in time, cough disappear time, fever subsided time, and total hospital stay were significantly less In the erythromycin group, the incidence of adverse reactions in children with erythromycin (32%) was significantly higher than the azithromycin group (10%). The differences between the two groups were statistically significant (P <0.05). Conclusion Sequential azithromycin treatment of mycoplasma pneumonia can significantly alleviate the clinical symptoms of children, rapid onset, shorter total hospital stay, the incidence of adverse reactions to reduce, worthy of clinical promotion.