心血管疾病患者常用的药物有强心剂、利尿剂、血管扩张剂和抗心失律常药物等。这些药物之间常会发生不利的相互作用,增加毒性或减弱疗效,必须予以注意。 强心剂:①强心剂与抗心律失常药物:如异搏定、普鲁卡因酰胺、心律平、胺碘酮和奎尼丁,均可使地高辛血浓度增加50％～100％。因此合用时,地高辛应酌减1/2～1/3,有条件者应做血浓度监测。②强心剂与利尿剂:大部分利尿剂有排钾作用,机体缺钾时洋地黄异常敏感,常规剂量即可发生洋地黄中毒,故地高辛与排钾利尿剂双氢克尿塞、速 Commonly used drugs in patients with cardiovascular disease are cardiac, diuretics, vasodilators and antidiabetic drugs often. These drugs often adverse interactions occur, increase toxicity or reduce the efficacy, we must pay attention. Cardiac agents: ① cardiac and antiarrhythmic drugs: such as verapamil, procainamide, cardiac rhythm, amiodarone and quinidine, can make digoxin blood concentration increased by 50% to 100%. Therefore, when combined, digoxin should be reduced by 1/2 to 1/3, the condition should be done to monitor blood levels. ② cardiac and diuretics: Most diuretics have row of potassium, digitalis is particularly sensitive when the body potassium deficiency, conventional dose can occur digitalis poisoning, it digoxin and row potassium diuretics hydrochlorothiazide, speed