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1980年Furchogtt等发现乙酰胆碱对离体血管的舒张作用依赖于血管内皮的完整,从而首次提出内皮源性舒张因子(EDRF)的概念。1987年在不同实验室同时证明EDRF就是一氧化氮(NO),随着对NO生物学作用了解的日益加深,NO在心血管病中发挥的重要作用受到越来越多的关注。本文就NO的生化
In 1980, Furchogtt et al found that the relaxation of acetylcholine on isolated blood vessels depends on the integrity of the vascular endothelium, and thus the concept of endothelium-derived relaxing factor (EDRF) was first proposed. In 1987, different laboratories at the same time proved that EDRF is nitric oxide (NO). With the deepening of the understanding of the biological role of NO, NO plays an important role in cardiovascular disease by more and more attention. This article on the biochemical NO