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目的 :探讨住院精神疾病患者肠梗阻的原因及影响因素。 方法 :对近 6年间我院住院的患者中 9例患者发生的 10次肠梗阻进行回顾分析。 结果 :发生肠梗阻时有 9次患者所服药物中有氯氮平 (90 % ) ,有 1例患者单一使用奋乃静。经停药或减少抗精神病药、灌肠及加用胃肠动力药 ,大多数患者病情很快好转 ,但有 1例突然死亡。 结论 :抗精神病药可能较易引起麻痹性肠梗阻 ,以氯氮平最为严重。氯氮平引发肠梗阻与剂量关系不大 ,而可能与个体对该药的敏感性有关
Objective: To investigate the causes and influencing factors of intestinal obstruction in hospitalized patients with mental illness. Methods: Ten patients with intestinal obstruction in 9 patients in our hospital in the past 6 years were retrospectively analyzed. RESULTS: Clozapine (90%) was taken in 9 of the patients when ileus occurred, and 1 patient was given perphenazine alone. After discontinuation or reduction of antipsychotics, enema and gastrointestinal motility drugs, the majority of patients recovered quickly, but one patient died suddenly. CONCLUSIONS: Antipsychotics may be more likely to cause paralytic ileus, with clozapine being the most serious. Clozapine-induced intestinal obstruction and dose is not related, but may be related to the individual’s sensitivity to the drug