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胶体释药系统作为抗肿瘤药物的靶向分布制剂,可提高抗癌药物的疗效。胶体释药系统大致可分为微胶囊、毫微囊、大分子复合物、红细胞载体、聚合物小球等。Marty 等采用去溶剂化技术制备了乙基纤维素毫微球,然而未能成功地分离出质地均匀的毫微球。作者改进了去溶剂化技术,分别用乙基纤维素和甲基纤维素制备了含有5-氟尿嘧啶(5-FU)的纤维素毫微球,其方法是在浓度为1.2 mg/ml 的5-FU 乙醇溶液中加入浓度分别为1％的乙基纤维素和吐温-80,在30℃下搅拌,用蒸馏水进行去溶剂化反应,在波长550nm 处控制去溶剂化程度,反应后得到的混悬液在500rpm 下剧烈搅拌10min,在玻璃板上铺成薄膜,30℃干燥即得白色易碎的材料。甲基纤维素毫微球的制备,系用1.0mg/ml 的5-FU 水溶液10ml,内含甲基纤维素1％,吐温-800.5％,加20％硫酸钠溶液作为去溶剂化试剂,在25±1℃条件下进行。其它过程同乙基纤维素。
Colloidal drug delivery system as a targeted distribution of anti-tumor drugs, can improve the efficacy of anti-cancer drugs. Colloidal drug delivery system can be divided into microcapsules, nanocapsules, macromolecular complexes, red blood cell carriers, polymer beads and so on. Marty et al. Used desolvation to prepare ethylcellulose nanospheres, however, they failed to separate nanospheres with uniform texture. The authors modified desolvation technology to prepare cellulose nanospheres containing 5-fluorouracil (5-FU) using ethyl cellulose and methyl cellulose, respectively, by incubating 5- FU ethanol solution was added at a concentration of 1% of ethyl cellulose and Tween-80, stirred at 30 ° C, desalinated with distilled water reaction at a wavelength of 550nm at desolvation degree control obtained after the reaction The suspension was stirred vigorously at 500 rpm for 10 min, spread on a glass plate and dried at 30 ° C to give a white, brittle material. Preparation of methylcellulose nanospheres, Department of 1.0mg / ml of 5-FU aqueous solution 10ml, containing methyl cellulose 1%, Tween -800.5%, add 20% sodium sulfate solution as a desolvating reagent, At 25 ± 1 ℃ conditions. Other processes with ethyl cellulose.