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研究人类白细胞抗原（HLA）与妊娠高血压综合征（PIH）关联的机制。采用非同位素标记的聚合酶链反应一顺序特异性寡核苷酸探针（PCR／SSO）杂交的方法，对30对PIH患者夫妇及14对正常对照夫妇进行了HLA-DQB1基因型的检测。结果：PIH患者夫妇HLA－DQB1*0502等位基因频率增高。结论：HLA—DQB1*0502可能是PIH的易感基因。
To investigate the mechanism of human leukocyte antigen (HLA) and pregnancy induced hypertension (PIH). HLA-DQB1 genotypes were detected in 30 couples of PIH and 14 couples of normal controls by PCR-SSO (polymerase chain reaction-non-specific PCR). Results: The frequency of HLA-DQB1 * 0502 alleles was increased in couples with PIH. Conclusion: HLA-DQB1 * 0502 may be a PIH susceptibility gene.