由于疟疾预防药应用增加,结果使有关该类药物毒性反应的报道亦有所增加。目前有关疟疾预防药对肝、肾、皮肤和骨髓的毒性已得到充分认识,并曾报道有5例病人在应用 Fansider(乙胺嘧啶-周效磺胺)后产生肺毒性和全身的病变,其中有两份报告还提到 As a result of the increased use of malaria prophylaxis, there has also been an increase in reports of toxic reactions to these drugs. At present, the toxicity of malaria prophylaxis to liver, kidney, skin and bone marrow has been fully recognized. It has been reported that 5 patients developed pulmonary toxicity and systemic disease after using Fansider (pyrimethamine-psoralen), among which Two reports also mentioned