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目的探讨术前经动脉化疗栓塞治疗婴儿肾母细胞瘤的可行性。方法2009年6月至2014年5月收治6例婴儿单侧肾母细胞瘤,术前评估肿瘤手术一期切除困难,所有婴儿均行经导管肾动脉化疗栓塞,术后4周内行肿瘤根治性手术切除,记录并分析6例婴儿的治疗结果、并发症及随访结果。结果6例婴儿介入后肿瘤体积均缩小,平均缩小39.03%(23.95%~61.8%),介入治疗总有效率达83.33%(5/6);手术中瘤体完整切除率为100%,无肿瘤破溃及污染腹腔情况。手术后随访时间平均为42.8个月,无肿瘤复发、远处转移及死亡。结论术前经动脉化疗栓塞治疗婴儿巨大肾母细胞瘤是安全、有效的,能为一期手术切除困难的肾母细胞瘤患儿提供一种新的治疗模式。
Objective To investigate the feasibility of preoperative transcatheter arterial chemoembolization in the treatment of infantile Wilms’ tumor. Methods From June 2009 to May 2014, 6 infants with unilateral nephroblastoma were treated. Tumor resection was performed on the first stage of resection. All infants underwent transcatheter arterial chemoembolization (PTCA) within 4 weeks after operation. Tumor radical surgery The outcomes, complications and follow-up results of 6 infants were excised, recorded and analyzed. Results The tumor volume of 6 infants decreased by 39.03% (23.95% -61.8%) on average, and the total effective rate of interventional treatment was 83.33% (5/6). The complete resection rate of the tumor was 100% Rupture and contamination of the abdominal cavity. The average follow-up time after surgery was 42.8 months, with no tumor recurrence, distant metastasis and death. Conclusions Preoperative transcatheter arterial chemoembolization in the treatment of infantile giant nephroblastoma is safe and effective and can provide a new therapeutic model for children with primary Wilms’ tumor who have difficulty in surgical resection.