采用超选择插管动脉内灌注尿激酶（ＵＫ）治疗２１例急性缺血性脑卒中患者。结果１３例完全再通（其中１例术后１天重新闭塞），４例部分再通，４例未通。１３例脑血栓形成患者中１１例完全再通，８例心源性脑栓塞患者中２例完全再通。临床有效率８０．９％。２１例中并发颅内出血４例，占１９％。本组在发病４８小时内ＣＴ尚未见大片梗塞灶的患者开始治疗后血管再通率高，出血并发症少。结合文献对该疗法的适应证、疗效及安全性进行了讨论。 21 patients with acute ischemic stroke were treated with superselective catheterization of urokinase (UK). Results of 13 cases recanalization (including 1 case of re-occlusion after 1 day), 4 cases recanalization, 4 cases failed. Of the 13 patients with cerebral thrombosis, 11 were completely recanalized and 2 of 8 patients with cardiogenic cerebral embolism were completely recanalized. Clinical efficiency of 80.9%. 21 cases complicated by intracranial hemorrhage in 4 cases, 19%. The group within 48 hours of onset of CT has not seen large infarct patients began treatment after the high rate of recanalization, bleeding complications less. The literature on the indications, efficacy and safety of the therapy were discussed.