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内皮细胞衍生的舒张因子其主要成分是一氧化氮(NO),它能激活鸟苷酸环化酶而使血管平滑肌舒张及松弛内脏平滑肌。许多研究证实,胎盘及脐带组织不仅产生NO,而且其产生的NO广泛参与围产期孕产妇及胎儿的各种生理病理调节,胎盘组织NO生成量下降可能是妊高征发病一重要因素。体内补充NO前体——L-精氨酸,对促进胎儿发育及控制早产、预防及治疗妊高征会起重要作用。低浓度NO吸入可降低肺动脉高压。
The main component of endothelial-derived relaxing factor is nitric oxide (NO), which activates guanylate cyclase to relax vascular smooth muscle and relax visceral smooth muscle. Numerous studies have shown that placenta and umbilical cord tissue not only produce NO, but also produce NO that is widely involved in various physiological and pathological changes of perinatal maternal and fetus. The reduction of NO production in placenta may be an important factor in the pathogenesis of PIH. In vivo NO precursors - L-arginine, to promote fetal development and control of premature delivery, prevention and treatment of pregnancy-induced hypertension play an important role. Low concentrations of NO inhalation can reduce pulmonary hypertension.