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目的:探讨心痛泰对心肌梗死大鼠血清ET-1、NO的干预作用。方法:制备心肌梗死大鼠模型,随机分成模型组,假手术组,心痛泰低、中、高剂量组及麝香保心丸组。模型组和假手术组以蒸馏水等量灌胃,其余各组分别给予相应药物及相应剂量灌胃,用药2周后分别检测各组大鼠血清ET-1、NO水平及心肌梗死面积。结果:与模型组相比,各用药组的心肌梗死面积均有减小,差异具有统计学意义(P<0.01);与心痛泰低剂量组相比,心痛泰中、高剂量组及麝香保心丸组梗死面积有减小,差异具有统计学意义(P<0.01),而心痛泰中、高剂量组及麝香保心丸组三者之间差异无统计学意义(P>0.05)。与假手术组相比,各治疗组及模型组ET-1表达均显著增加,NO表达均显著减少,差异有统计学意义(P<0.01);与模型组相比,各治疗组ET-1表达均减少,NO表达均增加,差异有统计学意义(P<0.01);心痛泰中、高剂量组及麝香保心丸组ET-1、NO表达改善均优于心痛泰低剂量组(P<0.01);而心痛泰中、高剂量组与麝香保心丸组3组组间差异无统计学意义P>0.05)。结论:心痛泰颗粒在一定程度上通过干预NO、ET-1的表达,抑制血管重塑,增加冠脉血流,减少模型大鼠心肌梗死面积。
Objective: To investigate the effect of Xintongtai on serum ET-1 and NO in myocardial infarction rats. Methods: The rat model of myocardial infarction was prepared and randomly divided into model group, sham-operation group, xintongtai low, middle and high dose group and Shexiang Baoxin Pill group. Rats in model group and sham operation group were given gavage with equal volume of distilled water. The other groups were given the corresponding drugs and corresponding doses of gavage respectively. Serum ET-1 and NO levels and myocardial infarct size of rats in each group were measured 2 weeks after treatment. Results: Compared with the model group, the area of myocardial infarction in each drug group decreased, the difference was statistically significant (P <0.01); Compared with the low dose group of Xintongtai, the middle and high dose Xintongtai group and the muskbon Heart infarction group infarct area has decreased, the difference was statistically significant (P <0.01), while the heartache in the high-dose group and Shexiang Baoxin Pills group was no significant difference between the three (P> 0.05). Compared with the sham-operated group, the ET-1 expression in each treatment group and model group was significantly increased, while the NO expression was significantly decreased (P <0.01). Compared with the model group, ET-1 (P <0.01). The improvement of ET-1 and NO expressions in Xintongtai medium and high dose group and Shexiangbaoxin Pills group were better than that of Xintongtai low dose group (P <0.01) <0.01). However, there was no significant difference between the three groups in the middle-dose, middle-dose and middle-dose groups of Xintongtai and Shexiang Baoxin Pills (P> 0.05). Conclusion: Xintongtai granule can inhibit the remodeling of coronary arteries, increase the coronary blood flow and decrease the area of myocardial infarction in model rats by interfering with the expression of NO and ET-1 to a certain extent.