Fluid-particle systems as commonly encountered in chemical, metallurgical and petroleum industries are mostly polydisperse in nature. However, the relations used to describe fluid-particle interactions are originally derived from monodisperse systems, with ad hoc modifications to account for polydispersity. In previous work it was shown that for bidisperse systems with moderate diameter ratios of 1:2 to 1:4, this approach leads to discrepancies, and a correction factor is needed. In this work we demonstrate that this correction factor also holds for more extreme diameter ratios of 1:5, 1:7 and 1:10, although the force on the large particles is slightly overestimated when using the correction factor. The main origin of the correction is that the void surrounding the large particles becomes less in case of a bidisperse mixture, as compared to a monodisperse system with the same volume fraction. We further investigated this discrepancy by calculating the volume per particle by means of Voronoi tessellation. However, the relations used to describe fluid-particle interactions are originally derived from monodisperse systems, with ad hoc modifications to account for polydispersity. In previous work it was shown that for bidisperse systems with moderation diameter ratio of 1: 2 to 1: 4, this approach leads to discrepancies, and a correction factor is needed. In this work we demonstrate that this correction factor also holds for more extreme diameter ratios of 1: 5, 1: 7 and 1:10, although the force on the large particles is slightly overestimated when using the correction factor. The main origin of the correction is that the void surrounding the large particles becomes less in case of a bidisperse mixture , as compared to a monodisperse system with the same volume fraction. We further investigated this discrepancy by calculating the volume per particle by means of Vo ronoi tessellation.