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目的:分析不孕症患者体内解脲支原体和沙眼衣原体DNA表达对其发病的临床意义。方法:选择患不孕症妇女220例做为病例组,另外选择150例正常妇女(已有1次以上怀孕史以及自愿进行人工流产)作为对照组。采用聚合酶链法(PCR)检测370例妇女宫颈分泌物中解脲支原体(UU)DNA和沙眼衣原体(CT)DNA,比较两组UU与CT水平差异,并分析病例组中UU、CT的水平与流产次数的相关性。结果:220例不孕症患者UU、CT的感染率为27.4%、24.5%显著高于对照组3.4%、2.5%,差异有统计学意义(P<0.01);病例组具有流产史的患者中UU、CT的含量与流产次数呈显著正相关(r=1.21,P<0.01)。结论:解脲支原体DNA和沙眼衣原体DNA是导致不孕症发生的重要因素,运用现代临床手段降低不孕症体内的UU、CT水平可能会成为治疗不孕症的又一临床途径。
Objective: To analyze the clinical significance of Ureaplasma urealyticum and Chlamydia trachomatis DNA expression in infertile patients. Methods: 220 infertile women were selected as the case group, another 150 normal women (more than one pregnancy history and voluntary induced abortion) were selected as the control group. UU DNA and C. trachomatis (CT) DNA in cervical secretions of 370 women were detected by polymerase chain reaction (PCR). The differences of UU and CT levels between the two groups were analyzed. The levels of UU and CT in the cases were analyzed Correlation with the number of abortions. Results: The infection rate of UU and CT in 220 cases of infertility was 27.4%, 24.5% was significantly higher than that of control group (3.4% and 2.5%, respectively) (P <0.01). In case group with abortion history The contents of UU and CT were positively correlated with the number of abortion (r = 1.21, P <0.01). Conclusion: Ureaplasma urealyticum DNA and Chlamydia trachomatis DNA are the important factors that lead to infertility. Using modern clinical methods to reduce the level of UU and CT in infertility may be another clinical approach to treat infertility.