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目的检测胸苷磷酸化酶(TP)及血管内皮生长因子(VEGF)在胃腺癌组织中的表达及其与患者年龄、性别、肿瘤大小、分化程度、浸润深度及淋巴结转移的关系,分析TP、VEGF的表达及其临床意义。方法采用免疫组织化学EnVisionTM法检测125例胃癌组织中TP、VEGF的表达,以30例肿瘤切缘正常胃黏膜组织作为对照。结果正常胃黏膜上皮不表达TP和VEGF,TP表达于癌细胞和间质浸润的炎症细胞。胃癌组织中TP和VEGF的阳性表达率分别为62.4%(78/125)和28.8%(36/125)。TP阳性表达与胃癌组织浸润深度及淋巴结转移有关;VEGF阳性表达与肿瘤大小及分化程度有关。结论胃癌组织TP表达可能提示肿瘤的局部浸润及淋巴结转移能力较强;肿瘤细胞分化差时VEGF表达增强,TP和VEGF阳性表达可能提示胃癌预后不良。
Objective To investigate the expression of thymidine phosphorylase (TP) and vascular endothelial growth factor (VEGF) in gastric adenocarcinoma and its relationship with age, gender, tumor size, differentiation, depth of invasion and lymph node metastasis. Expression of VEGF and its clinical significance. Methods EnVisionTM immunohistochemistry was used to detect the expression of TP and VEGF in 125 cases of gastric carcinoma. The normal gastric mucosa of 30 cases was used as the control. Results The normal gastric mucosal epithelium did not express TP and VEGF, but TP was expressed in cancer cells and interstitial infiltrating inflammatory cells. The positive rates of TP and VEGF in gastric cancer tissues were 62.4% (78/125) and 28.8% (36/125) respectively. The positive expression of TP was related to the depth of invasion and lymph node metastasis of gastric cancer. The positive expression of VEGF was related to the size and differentiation of tumor. Conclusion The expression of TP in gastric cancer may be a sign of local invasion and lymph node metastasis. VEGF expression is enhanced in poorly differentiated tumor cells. The positive expression of TP and VEGF may indicate the poor prognosis of gastric cancer.