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作为遗传性心律失常之一的长QT综合征(LQTS),现已发现有12型,其中在中国以LQT2为常见,可诱发尖端扭转型室性心动过速及室颤,临床上以反复发作的晕厥及常导致的猝死为特征。自主神经通过释放神经递质作用于受体调节离子通道,从而对某些心律失常起到一定的作用,而迷走神经通过直接或间接作用对多种心律失常具有一定的保护作用。本文主要对LQT2的研究进展、迷走神经与LQT2的关系以及其在心律失常中发挥的作用作一综述。
As one of the inherited arrhythmia long QT syndrome (LQTS), has been found to have 12, which in China LQT2 is common, can induce torsades de pointes ventricular tachycardia and ventricular fibrillation, recurrent clinical Syncope and often caused by sudden death are characterized. Autonomic nerves play a role in certain arrhythmias by releasing neurotransmitters to the receptor-regulated ion channels, whereas vagal nerves have a protective effect against a variety of arrhythmias either directly or indirectly. This article mainly reviews the research progress of LQT2, the relationship between vagus nerve and LQT2 and its role in arrhythmia.