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目的评估大剂量因卡膦酸钠的长期应用对骨细胞密度影响。方法 30只猎犬,犬龄1年,按体重随机分成3组(每组雌雄各5只):分别每天给予口服因卡膦酸钠低剂量组0.3 mg.kg-1和高剂量组0.6 mg.kg-1,对照组犬给予口服乳糖12 mg.kg-1.d-1,所有犬持续给药3年。处死前进行四环素双标,处死后取左侧第九肋骨进行组织形态计测和骨皮质表面骨细胞密度测量。结果组织形态计测表明高剂量双膦酸盐组的骨激活频率明显低于对照组,降低了86.5%,而低剂量双膦酸盐组的骨激活频率与对照组无统计学差异。低剂量组和高剂量组的骨细胞密度都明显高于对照组,分别增加了31.8%和56.3%。结论双膦酸盐长期应用可抑制骨转换,增加骨皮质表面的骨细胞密度。
Objectives To assess the long-term effects of high-dose incarconsat sodium on bone cell density. Methods Thirty dogs were randomly divided into 3 groups (5 male and female in each group). The dogs were given 0.3 mg · kg-1 of low-dose of camptothecin sodium and 0.6 mg of high-dose rhinoceros. kg-1, the control group dogs given oral lactose 12 mg.kg-1.d-1, all dogs continued administration for 3 years. Tetracycline double standard before sacrifice, after sacrifice take the left of the ninth rib morphology measurement and measurement of bone cortical bone cell surface density. Results Histomorphometry showed that the frequency of bone activation in high-dose bisphosphonate group was significantly lower than that in control group (86.5%), while the frequency of bone activation in low-dose bisphosphonate group was not significantly different from that in control group. The osteoblast densities of low-dose group and high-dose group were significantly higher than those of the control group, increasing by 31.8% and 56.3% respectively. Conclusion Long-term use of bisphosphonates can inhibit bone turnover and increase the density of bone cells on the cortical surface.