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目的观察比较氯沙坦配氢氯噻嗪(观察组)与苯那普利配氢氯噻嗪(对照组)对老年轻中度原发性高血压的临床疗效和耐受性。方法103例老年原发性高血压病患者(舒张压为95～110mmHg),经过一周安慰剂洗脱期后被随机分为观察组(50mg/12.5mg)和对照组(10mg/12.5mg),每日服药1次,经过4周的治疗观察,99例完成了本研究。舒张压下降到正常或下降10～19mmHg以上为有效。结果两组患者血压均有明显下降。治疗组降血压疗效有效率达80%,对照组效率77%。结论氯沙坦配氢氯噻嗪是治疗高血压药物的最佳联合,其固定剂量复方制剂降压效果肯定,安全性、耐受性好,毒副作用少,对代谢的影响小,尤其适用于老年人轻、中度高血压。
Objective To compare the clinical efficacy and tolerability of losartan with hydrochlorothiazide (observation group) and benazepril with hydrochlorothiazide (control group) on senile mild to moderate essential hypertension. Methods 103 elderly patients with essential hypertension (diastolic blood pressure 95 ~ 110mmHg) were randomly divided into observation group (50mg / 12.5mg) and control group (10mg / 12.5mg) after a week of placebo elution period, Once a day, after 4 weeks of treatment, 99 patients completed the study. Diastolic blood pressure dropped to normal or decreased 10 ~ 19mmHg above is valid. Results Both groups of patients had a significant decrease in blood pressure. Antihypertensive treatment effective rate of 80% in the control group, the control group efficiency of 77%. Conclusion Losartan with hydrochlorothiazide is the best combination of antihypertensive drugs, its fixed dose of compound antihypertensive effect is certain, safety, tolerability, less toxic side effects, little effect on metabolism, especially for the elderly light , Moderate hypertension.