鼠疫为危害人类健康的甲类传染病,由于我国存在着多种类型的鼠疫疫源地,鼠疫菌的特征及致病力不同,因此将不同疫源地的菌株进行基因分型,探讨其亲缘关系,对于鼠疫突发疫情的追溯具有重要意义。多位点可变数目串联重复序列分析方法被认为分型能力较好,但是可变数目串联重复序列(VNTR)位点的选择是分型的关键所在,该文主要介绍VNTR在鼠疫菌基因分型中的应用进展,为基因分型提供参考。 Plague is a group A contagious disease that endangers human health. Due to the existence of many types of plague foci in our country, the characteristics and virulence of plague bacterium are different, so the strains of different foci are genotyped and their relatives The relationship between the epidemic outbreaks of the plague is of great significance. The method of multiple locus variable number tandem repeat analysis is considered to be a better typing method, but the selection of VNTR loci is the key to typing. Type of application progress, provide a reference for genotyping.