甲状腺相关眼病（ＴＡ）是最常见的眼眶病。作为自身免疫性疾病，其发病机制尚不清。在免疫反应局部表达的粘附分子起关键的调节作用。细胞间粘附分子－１（ＩＣＡＭ－１）与其受体白细胞功能相关抗原－１（ＬＦＡ－１）的相互作用对于ＴＡＯ的进展和持续起重要作用。其功能包括：激活并使单核细胞进入球后结缔组织，协助单核细胞在血管外移动并选择靶细胞识别并呈递抗原。可溶性粘附分子，尤其是ＩＣＡＭ－１和ＥＬＡＭ－１，可以作为ＴＡＯ球后结缔组织炎症的标志。现综述粘附分子及其与甲状腺相关眼病关系的研究的最新进展。 Thyroid-related eye disease (TA) is the most common orbital disease. As an autoimmune disease, its pathogenesis is unclear. Adhesion molecules that are locally expressed in the immune response play a key regulatory role. Interaction of intercellular adhesion molecule-1 (ICAM-1) with its receptor, leukocyte function-associated antigen-1 (LFA-1), plays an important role in the progression and persistence of TAO. Its functions include activating and allowing mononuclear cells to enter the posterior sphere of the connective tissue, assisting mononuclear cells to migrate extravascularly and selecting target cells to recognize and present antigens. Soluble adhesion molecules, especially ICAM-1 and ELAM-1, can be used as a marker of connective tissue inflammation after TAO. Now reviewed the latest research progress of adhesion molecules and thyroid-related eye disease.