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1976年作者开始对唇裂危险性增加的孕妇作了前瞻性研究,预以补充多种维生素(含2,000IU 的维生素 A,1mg 维生素 B_1,1mg 维生素 B_2,1mg维生素 B_6,50mg 维生素 C,100IU 的维生素 D_3,2mg 维生素 E,10mg 菸酰胺及1mg 泛酸钙)。研究对象为健康妇女,曾生过一个唇裂(有或无腭裂)的孩子,但无其它口面部裂家族史。嘱其每天服用3片上述的多种维生素及10mg 叶酸,在怀孕前3个月就开始并持续服药至妊娠第3个月的终末.
In 1976, the authors began a prospective study of pregnant women with an increased risk of cleft lip, pretreated with multivitamins (2,000 IU of vitamin A, 1 mg of vitamin B_1, 1 mg of vitamin B_2, 1 mg of vitamin B_6, 50 mg of vitamin C, 100 IU of vitamin D_3, 2 mg vitamin E, 10 mg nicotinamide and 1 mg calcium pantothenate). The study was performed on healthy women who had had a child with a cleft lip (with or without cleft palate) but no other family history of mouth fissures. Instruct them to take three of the above-mentioned multi-vitamins and 10 mg of folic acid daily for three months before starting and continuing to take medication until the third trimester of pregnancy.