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目的:了解MDM2、p63和Ki-67在宫颈鳞状细胞癌组织中的表达情况。方法:应用免疫组化SP法检测63例宫颈鳞状细胞癌和15例正常组织中MDM2、p63和Ki-67蛋白的表达。结果:宫颈癌组织中MDM2、p63和Ki-67的阳性表达率分别为57.14%(36/63),34.88%(21/63),44.44%(28/63),均显著高于正常对照组(P<0.05)。MDM2、p63和Ki-67的表达与宫颈癌的组织分化,浸润深度及淋巴结有无转移有关,而与年龄分组无关。结论:MDM2、p63和Ki-67的异常表达可作为宫颈癌诊断、判断预后的辅助指标。
Objective: To investigate the expression of MDM2, p63 and Ki-67 in cervical squamous cell carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of MDM2, p63 and Ki-67 in 63 cases of cervical squamous cell carcinoma and 15 cases of normal tissue. Results: The positive rates of MDM2, p63 and Ki-67 in cervical cancer were 57.14% (36/63), 34.88% (21/63) and 44.44% (28/63) respectively, which were significantly higher than those in normal control group (P <0.05). The expressions of MDM2, p63 and Ki-67 were related to the histological differentiation, depth of invasion and lymph node metastasis, but not to the age group. Conclusion: The abnormal expression of MDM2, p63 and Ki-67 can be used as auxiliary indicators for diagnosis and prognosis of cervical cancer.