脑瘤虽有多种治疗方法,但其侵袭性使之成为不治之症。在组织病理分级上的差异,对脑瘤准确分类造成很大困难。我们可以通过分析体液中与肿瘤密切相关的的蛋白生物标志物来区分各个脑瘤亚型,这种分析方法既可为肿瘤的分类提供相关线索,也可能为个性化治疗找到病理生理学靶点。过去的数十年内,许多研究报告用人体组织,生物体液,细胞系和动物模型对脑瘤蛋白质组进行分析,确定了一批具有诊断、预后、预测、和治疗价值的生物学标志物。 Although there are many treatments for brain tumors, their aggressiveness makes them incurable. Differences in histopathological grades make it difficult to accurately classify brain tumors. We can distinguish each brain tumor subtype by analyzing protein biomarkers closely related to tumors in body fluids. This analysis method can provide clues for the classification of tumors, and it can also find pathophysiological targets for personalized therapy. Over the past few decades, many studies have used human tissues, biological fluids, cell lines, and animal models to analyze brain tumor proteomes and identified a number of biological markers with diagnostic, prognostic, predictive, and therapeutic value.