Rho Rock信号通路介导多种平滑肌与非平滑肌功能异常的疾病 ,是近年的研究热点之一。它通过调节细胞内微丝骨架的聚合状态 ,参与多种细胞的生物学行为。在支气管哮喘、血管痉挛、器官纤维化和肿瘤的浸润转移中均发现Rho Rock信号转导通路的异常活化。该文对该信号通路的组成、活化、调节等生物学特征及其在多种疾病发生机制中作用的研究进展作一综述 Rho Rock signaling pathway mediates a variety of disorders of smooth muscle and non-smooth muscle dysfunction, is one of the hot spots in recent years. It is involved in the biological behavior of many kinds of cells by regulating the polymerization state of intracellular microfilament scaffolds. Abnormal activation of the Rho-Rock signaling pathway was found in bronchial asthma, vasospasm, organ fibrosis, and invasiveness and metastasis of tumors. This review summarizes the biological characteristics of the signaling pathway, such as its composition, activation and regulation, and its role in the pathogenesis of various diseases