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目的 :检测溃疡性结肠炎患者 (UC)的组织及血清中白细胞介素 - 8(IL - 8)的含量 ,了解其在溃疡性结肠炎发病中的作用。方法 :收集 34例经内镜检查证实的UC患者结肠黏膜组织和血清标本 ,采用放射免疫分析检测IL - 8的含量。并与正常对照组进行比较。结果 :UC组中病变局限组血清和组织中IL - 8含量分别为(1 81 5 7± 2 6 6 7)ng/L、(71 4 80± 1 84 30 )pg/mg病变广泛组血清和组织中IL - 8含量分别为 (2 1 7 91± 5 8 1 1 )ng/L、(1 0 5 6 5 0± 30 8 1 0 )pg/mg与 32例正常对照组患者比较有显著性差异。结论 :UC患者的组织和血清中IL - 8含量明显升高 ,随着病变范围的扩大和病变程度的增加 ,其含量亦有增高的趋势
Objective: To detect the content of interleukin - 8 (IL - 8) in the tissue and serum of patients with ulcerative colitis (UC) and to find out its role in the pathogenesis of ulcerative colitis. Methods: Colon mucosa tissue and serum samples from 34 UC patients confirmed by endoscopy were collected. The content of IL - 8 was detected by radioimmunoassay. And compared with the normal control group. Results: The levels of IL - 8 in serum and tissue in the limited group of UC were (1 81 57 ± 2 6 6 7) ng / L and (71 4 80 ± 1 84 30) pg / mg respectively The levels of IL - 8 in the tissue were (2 1 7 91 ± 5 8 1 1) ng / L, (105 6 5 0 ± 30 8 1 0) pg / mg respectively, compared with 32 normal controls difference. Conclusion: The content of IL - 8 in the tissues and serum of patients with UC is obviously increased. The content of IL - 8 also increases with the expansion of the lesion and the increase of the degree of the lesion