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目的总结5例因口服抗甲亢药物治疗甲亢致肝功能损害的临床特点。方法回顾性分析5例甲状腺功能亢进患者因口服抗甲亢药物致肝功能损害的临床资料。结果304例甲亢患者口服抗甲亢药物治疗甲状腺功能亢进,其中5例在用药后2～12周内出现肝功能损害,占总病例的1.6%,停用硫脲类药物,改用其他抗甲亢药物和保肝、降低转氨酶的药物治疗,病情严重者加用肾上腺糖皮质激素,治疗1～2周后,复查肝功能均恢复正常。结论甲抗治疗中,口服抗甲亢药之前需检查肝功,治疗过程中要注意复查肝功,有利于及时发现肝功能损害。若甲亢病情好转却反而出现乏力加重、食欲不振等症状则应怀疑药物所致肝功能损害可能。
Objective To summarize the clinical features of 5 cases of hepatic dysfunction caused by hyperthyroidism treated with oral antihyperhybrids. Methods The clinical data of 5 patients with hyperthyroidism due to oral anti-hyperthyroidism drugs were retrospectively analyzed. Results 304 cases of patients with hyperthyroidism oral anti-hyperthyroidism treatment of hyperthyroidism, including 5 cases of liver damage within 2 to 12 weeks after treatment, accounting for 1.6% of the total cases, the withdrawal of thiourea drugs, switch to other anti-hyperthyroidism drugs And liver, reduce the aminotransferase drug treatment, severe cases plus adrenal glucocorticoid treatment 1 to 2 weeks after the review of liver function returned to normal. Conclusion A treatment, oral anti-hyperthyroidism before the need to check liver function, the course of treatment should pay attention to review the liver function is conducive to the timely detection of liver damage. If the condition of hyperthyroidism is improved, but fatigue appears aggravating, loss of appetite and other symptoms should be suspected of liver damage caused by drugs may be.