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目的探讨颈部胸腺样分化的癌的临床病理类型。方法入选2013年1月至2013年12月于我院手术切除颈部软组织和颈部甲状腺组织肿瘤90例,将术中所切除的肿瘤组织和标本送入病理室检查,将标本进行HE染色、免疫组化染色,根据胸腺样分化的癌的形态、特征、分布等特点,评估恶性胸腺样组织及良性胸腺样囊肿上皮组织的特异性标记抗体CD5、CD117、CK19、TTF-1以及Tg阳性率情况。结果恶性胸腺样组织上皮的特异性标记抗体CD5、CD117、CK19、TTF-1、Tg检测阳性率与良性胸腺样囊肿上皮组织比较,差异有统计学意义(P<0.05)。结论颈部胸腺样分化的癌临床病理类型与病变组织来源相关,免疫组化有助于鉴别诊断,可为病理诊断及临床预后提供理论依据。
Objective To investigate the clinicopathological types of cervical thymus-like carcinoma. Methods Totally 90 cases of thyroidectomy of neck soft tissue and neck were selected from January 2013 to December 2013 in our hospital. Tumor tissues and specimens resected in operation were sent to the pathological examination. The specimens were stained with HE, Immunohistochemical staining was used to evaluate the positive rate of CD5, CD117, CK19, TTF-1 and Tg in malignant thymus-like tissues and benign thymus-like cysts according to the morphology, features and distribution of thymus-like carcinoma Happening. Results The positive rate of CD5, CD117, CK19, TTF-1 and Tg in malignant thymus tissue epithelium was significantly higher than that in benign thymic cyst (P <0.05). Conclusion The clinical and pathological types of cervical thymus-like differentiation correlate with the source of the diseased tissue. Immunohistochemistry may be helpful for differential diagnosis, which may provide a theoretical basis for pathological diagnosis and clinical prognosis.