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目的:探讨不同剂量精氨酸(Arg)对重度创伤病人术后血清Arg含量的影响。方法:选择重度创伤术后病人72例,分别按服用Arg 0、10、20和30 g/d随机分为A(n=20)、B(n=17)、C(n=18)和D(n=17)组,观察14 d。病人均采用等氮、等热量营养支持,分别于术后第1、7和14天清晨空腹抽取外周静脉血,检测血清Arg含量,并统计分析。结果:术后第7和第14天,A组和B组病人血清Arg水平明显下降,而C组和D组Arg水平明显升高,与术后第1天比有显著性差异(P<0.05)。术后第7和第14天,C组和D组病人Arg水平恢复至正常,与A组和B组比均有显著性差异(P<0.05)。结论:重度创伤病人术后应用Arg 20 g/d或30 g/d,有助于改善血清Arg含量。
Objective: To investigate the effects of arginine (Arg) at different doses on postoperative serum levels of Arg in patients with severe trauma. Methods: Seventy two patients with severe traumatic injury were randomly divided into A (n = 20), B (n = 17), C (n = 18) and D (n = 17) group, observed for 14 days. Patients were treated with equal nitrogen and isocaloric caloric support. Peripheral venous blood was drawn on fasting days 1, 7 and 14 after operation respectively. Serum Arg levels were measured and statistically analyzed. Results: On the 7th and 14th day after surgery, serum Arg level was significantly decreased in group A and group B, while Arg levels in group C and group D were significantly higher than those on day 1 after operation (P <0.05 ). On the 7th and 14th day after operation, the Arg level of patients in group C and group D returned to normal, which was significantly lower than that of group A and group B (P <0.05). CONCLUSION: Arg 20 g / d or 30 g / d after severe trauma patients can help to improve serum Arg content.