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本文旨在评价阿片依赖行为是否存在性别差异。纳洛酮催促戒断研究:20只大鼠,单次注射吗啡后1小时注射纳洛酮。评价大鼠戒断症状,同时应用HPLC-UV方法测定血浆中吗啡和M3G浓度。自然戒断研究:97只大鼠,吗啡组以剂量递增法给药28天,于最后一次给药后,评价大鼠自然戒断症状和血浆中吗啡以及M3G的含量。急性给药催促戒断的戒断症状未观察到性别差异。自然戒断后身体戒断症状存在性别差异,雄鼠重于雌鼠(P<0.05)。在急性给药实验和慢性给药实验中,吗啡的Cmax雄鼠比雌鼠含量高,M3G的Cmax雌鼠比雄鼠含量高。吗啡药代动力学特征在急性给药实验和慢性给药实验中存在性别差异。成瘾大鼠自然戒断后身体戒断症状的程度和血浆中吗啡、M3G浓度以及M3G/MOR的比值相关。
The purpose of this article is to evaluate the gender differences in opioid dependence. Naloxone urges abstinence study: Twenty rats were injected with naloxone 1 hour after a single injection of morphine. The withdrawal symptoms of rats were evaluated, and the concentrations of morphine and M3G in plasma were determined by HPLC-UV method. Natural withdrawal study: 97 rats, morphine group were dosed for 28 days by dose escalation. After the last administration, symptoms of natural withdrawal and plasma morphine and M3G content were evaluated. No differences were observed in the withdrawal symptoms due to acute administration. There was a gender difference in physical withdrawal symptoms after natural withdrawal, male rats were heavier than female rats (P <0.05). In the acute administration and chronic administration experiments, the Cmax male morphine was higher than the female mice and the Cmax female M3G was higher than the male rats. Morphine Pharmacokinetic Characteristics There are gender differences in acute and chronic drug administration trials. The extent of withdrawal symptoms in natural addicts after spontaneous withdrawal correlated with plasma morphine, M3G concentration, and M3G / MOR ratio.