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为探讨25％维生素C治疗痔核的作用机理,作者开展了数项实验研究,观察到该药可使注射局部的组织发生严重的炎症—肉芽肿形成过程;对兔眼结、角膜有轻度刺激作用;对家兔肠系膜微循环有促进作用,但为时暂短(约30′);对家兔出、凝血时间及离体兔耳血管灌流量无显著影响。据此推测,该药治疗痔核的机理可能是,将具有刺激性的该药连续多次注射于痔核局部,使痔周及痔静脉内膜产生较严重的炎症反应,随后该反应导致的的痔周及痔静脉内膜的纤维组织增生压迫或堵塞痔静脉,阻断血流,终致痔核皱缩、平复。
In order to investigate the action mechanism of 25% vitamin C in the treatment of hemorrhoidal nucleus, the author carried out several experimental studies and observed that the drug can cause severe inflammation of the injected tissue - formation of granuloma; mild stimulation of rabbit eye and cornea. Effect; promote the mesenteric microcirculation of rabbits, but temporarily short (about 30’); no significant effect on the rabbit rabbits, coagulation time and isolated rabbit ear vascular irrigation. Based on this speculation, the drug’s mechanism for the treatment of deaf nuclei may be that the irritant drug is injected multiple times into the nucleus pulposus, causing severe inflammatory reactions in the periorbital and iliac vein intima. Peripheral fibrosis of the peritoneal veins of the temporal and iliac veins oppresses or blocks the iliac veins, blocks blood flow, and eventually causes nucleus folds to shrink and calm down.