The use of intense anticoagulation and antiplatelettherapy in acute myocardial infarction (AMI)potentially increases the risk of bleeding complicationsduring percutaneous coronary intervention (PCI) via thetransfemoral approach. Recently, the transradial accesshas been increasingly employed as an alternative meansfor diagnostic and interventional procedures. Lowincidence of vascular access site bleeding complicationssuggests the transradial approach as a safe alternative tothe femoral technique in AMI, particularly under anaggressive anticoagulation/antiplatelet regimen.Nevertheless, the safety and feasibility of employing thetransradial approach for primary PCI in AMI has not beenthoroughly investigated so far. The use of intense anticoagulation and antiplatelettherapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications peruring percutaneous coronary intervention (PCI) via the trans femoral approach. Recently, the transradial accesshas been increasingly employed as an alternative means for diagnostic and interventional procedures. vascular access site bleeding complicationssuggests the transradial approach as a safe alternative tothe femoral technique in AMI, particularly under anaggressive anticoagulation / antiplatelet regimen. Yet, the safety and feasibility of employing thetransradial approach for primary PCI in AMI has not beenthoroughly investigated so far.