为了研究紫杉醇治疗小鼠Ｓ１８０肉瘤的３１ＰＭＲＳ参数的变化及这些参数的变化是否早于常规观察的瘤体积的变化．方法：利用表面线圈３１ＰＮＭＲ方法，研究小鼠皮下接种的Ｓ１８０肉瘤．结果：用药４８ｈ后给药组的ＰＣｒ／Ｐｉ、βＮＴＰ／Ｐｉ、ＰＭＥ／βＮＴＰ比值与对照组有显著性差别（Ｐ＜０．０５），而肿瘤体积在给药组和对照组之间无显著性差别，３１ＰＭＲＳ参数的变化早于瘤体积变化．结论：小鼠Ｓ１８０肉瘤３１ＰＭＲＳ不仅可以给出定量的结果，而且可以较早地显示出治疗的效果． In order to investigate the changes in 31PMRS parameters of paclitaxel-treated mouse S180 sarcoma and whether the changes of these parameters were earlier than those of conventional observed tumor volume. METHODS: S180 sarcoma cells were inoculated subcutaneously in mice using surface coil 31PNMR method. Results: The ratio of PCr / Pi, βNTP / Pi, PME / βNTP in the treated group after 48h treatment was significantly different from that in the control group (P <0.05), while the tumor volume was significantly lower in the treated group and the control group No significant difference between the 31PMRS parameters change earlier than the tumor volume changes. CONCLUSIONS: The mouse S180 sarcoma 31 PMRS not only gives quantitative results, but also shows the effect of treatment earlier.