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目的:探讨喉癌组织内皮素-1(ET-1)和血管内皮生长因子-C(VEGF-C)的表达与预后的关系。方法:采用免疫组织化学方法检测80例喉癌组织及62例喉良性组织ET-1和VEGF-C的表达,探讨二者与喉癌患者预后的关系。结果:喉癌组织ET-1及VEGF-C阳性率分别为56.3%和57.5%,喉良性组织分别为19.4%和21.0%,差别具有统计学意义(P<0.05);ET-1及VEGF-C与喉癌患者TNM分期、淋巴转移显著相关(P<0.05),与组织学分级、年龄及性别无关(P>0.05)。结论:ET-1与VEGF-C参与喉癌的发生机制,且与肿瘤的转移侵袭等生物学行为显著相关。
Objective: To investigate the relationship between the expression of endothelin-1 (ET-1) and vascular endothelial growth factor-C (VEGF-C) and prognosis in laryngeal carcinoma. Methods: The expressions of ET-1 and VEGF-C in 80 cases of laryngeal carcinoma and 62 cases of laryngeal benign tissue were detected by immunohistochemistry. The relationship between them and the prognosis of laryngeal carcinoma was analyzed. Results: The positive rates of ET-1 and VEGF-C in laryngeal carcinoma were 56.3% and 57.5%, respectively, and those in laryngeal benign tissues were 19.4% and 21.0% respectively (P <0.05) C was significantly associated with TNM stage and lymphatic metastasis (P <0.05), but not with histological grade, age and gender (P> 0.05). Conclusions: ET-1 and VEGF-C are involved in the pathogenesis of laryngeal carcinoma and are significantly associated with biological behaviors such as tumor invasion and metastasis.