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TGF-β是一种具有控制增殖和分化等生物过程的自分泌或旁分泌生长因子[2]。TGF-β及其受体、细胞内下游信号转导分子的突变在脏器纤维化和肿瘤等疾病的发病中很重要[1],TGF-β在肝脏的正常生理功能、肝纤维化和肝癌的发生发展中都非常重要,准确地分析TGF-β及其受体在肝细胞癌
TGF-β is an autocrine or paracrine growth factor that controls biological processes such as proliferation and differentiation [2]. Mutation of TGF-β and its receptor, intracellular downstream signal transduction molecules is very important in the pathogenesis of organ fibrosis and tumor [1], TGF-β in normal liver function, liver fibrosis and liver cancer Of the occurrence and development are very important and accurate analysis of TGF-β and its receptor in hepatocellular carcinoma