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目的 :探讨食管鳞癌 p2 7和 p5 3的表达及其意义。方法 :应用免疫组化S -P法检测 112例食管鳞癌组织p2 7和 p5 3基因蛋白的表达 ,并分析其与临床分期、组织学分级及预后的关系。结果 :p2 7阳性表达多见于高分化组 (Ⅰ～Ⅱ级 )及临床早期 (Ⅰ～Ⅱ期 )病例 ;而p5 3阳性表达多见于低分化组 (Ⅲ～Ⅳ级 )及临床晚期 (Ⅲ～Ⅳ期 )病例 (P <0 .0 5 )。p2 7与p5 3阳性表达相平行。结论 :食管癌的发生发展是多因素作用的结果 ,p2 7和 p5 3的表达与食管癌临床病理指标有关 ,二者联合检测对评价食管鳞癌的恶性程度 ,判断预后及指导治疗具有重要意义。
Objective: To investigate the expression and significance of p2 7 and p5 3 in esophageal squamous cell carcinoma. Methods: The expressions of p2 7 and p5 3 protein in 112 cases of esophageal squamous cell carcinoma were detected by immunohistochemical S-P method. The relationship between p2 7 and p5 3 protein was analyzed by clinical staging, histological grade and prognosis. Results: The positive expression of p27 was more common in well-differentiated group (grade Ⅰ ~ Ⅱ) and early clinical stage (Ⅰ ~ Ⅱ), while the positive expression of p53 was more common in poorly differentiated group (grade Ⅲ ~ Ⅳ) Ⅳ) cases (P <0.05). p2 7 is parallel to p5 3 positive expression. Conclusion: The occurrence and development of esophageal cancer are the result of multiple factors. The expressions of p27 and p5 3 are correlated with clinicopathological features of esophageal cancer. The combined detection of esophageal squamous cell carcinoma and esophageal squamous cell carcinoma is of great significance in evaluating malignancy, prognosis and guiding treatment .