目的探讨11例艾滋病合并马尔尼菲青霉病患者的临床特征。方法对2002-2004年来我院住院和门诊就诊的11例艾滋病合并马尔尼菲青霉病患者的一般资料、临床表现、体征、实验室检查进行分析。结果11例患者中男9例,女2例,临床症状除非特征性的表现如发热、消瘦、贫血、肝脾淋巴结肿大外,8例合并有皮疹；3例有消化道症状,其中2例腹痛,1例腹泻、排红色湖状便：1例吞咽困难,进食梗阻感；5例有呼吸系统症状；1例关节痛；2例合并口腔念珠菌感染、4例骨髓、1例痰、1例血涂片、8例皮疹刮片或分泌物涂片、2例淋巴结和皮肤病理活检切片中可见成堆的PAS染色阳性的圆形或腊肠形分隔孢子。11株分离株经形态学、培养皆证实为马尔尼菲青霉,其中4株分离株经DNA分析证实为马尔尼菲青霉。结论艾滋病患者机会性感染中马尔尼菲青霉病的临床表现多样,且多伴有皮疹 Objective To investigate the clinical features of 11 AIDS patients with penicillium marneffei. Methods The general data, clinical manifestations, signs and laboratory tests of 11 HIV / AIDS patients with penicillium marneffei who were hospitalized and outpatient in our hospital from 2002 to 2004 were analyzed. Results Among the 11 patients, 9 were males and 2 were females. The clinical symptoms were accompanied by a rash in 8 cases except for the characteristic manifestations such as fever, weight loss, anemia and hepatosplenomegaly. Three patients had gastrointestinal symptoms, of which 2 Abdominal pain, 1 case of diarrhea, row of red lake like: 1 case of dysphagia, eating obstruction; 5 cases of respiratory symptoms; 1 case of joint pain; 2 cases of oral candidiasis, 4 cases of bone marrow, 1 case of sputum, 1 Cases of blood smears, 8 cases of rash smears or secretions smear, 2 cases of lymph nodes and skin biopsy sections can be seen piles of PAS-positive round or sausage-shaped separation of spores. Eleven isolates were confirmed by morphology and culture to be Penicillium marneffei, of which four isolates were confirmed by DNA analysis to be Penicillium marneffei. Conclusion The clinical manifestations of penicillium marneffei in opportunistic infections in AIDS patients are diverse and often accompanied by rash