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目的研究学龄前儿童肠道内腺病毒36型(Ad-36)的存在情况,及其与体质指数和血压的关系。方法从2013年1月-2014年10月,在就诊的学龄前儿童中随机抽取肥胖儿童33例,体重正常儿童38例,采用酶联免疫吸附试验(ELISA)检测新鲜粪便中的Ad-36,并测量儿童的体重、身高和血压。整个过程采用双盲法进行检测及测量。结果在71例儿童中,Ad-36阳性的有36例,平均年龄(4.36±0.74)岁,男20例,阳性率为50.7%;阴性的有35例,平均年龄(4.56±0.39)岁,男16例,阴性率为49.3%;阳性组和阴性组性别、年龄差别无统计学意义(P>0.05);阳性组和阴性组的肥胖率分别为69.4%和29.6%(P<0.05);两组的体质指数(BMI)分别为(19.27±2.55)和(16.38±2.13)kg/m2(P<0.05);血压分别为(103.06±11.40)/(68.58±8.12)mm Hg和(95.37±5.40)/(60.26±4.04)mm Hg(P<0.05)。结论学龄前儿童肠道Ad-36的感染与体质指数和血舒张压升高有一定的相关性,并提示与肥胖的发生有一定的影响。
Objective To study the presence of enteric adenovirus type 36 (Ad-36) in preschool children and its relationship with body mass index and blood pressure. Methods From January 2013 to October 2014, 33 obese children and 38 normal weight children were selected randomly from pre-school children. Ad-36 in fresh feces was detected by enzyme-linked immunosorbent assay (ELISA) And measure the child’s weight, height and blood pressure. The whole process using double-blind method for testing and measurement. Results Of the 71 children, 36 were positive for Ad-36, with a mean age of (4.36 ± 0.74) years and 20 males, with a positive rate of 50.7%; 35 were negative, with an average age of 4.56 ± 0.39 years, There were 16 males and 16 females, with a negative rate of 49.3%. There was no significant difference in sex and age between the positive and negative groups (P> 0.05). The obesity rates in the positive and negative groups were 69.4% and 29.6%, respectively (P <0.05). The body mass index (BMI) of the two groups were (19.27 ± 2.55) and (16.38 ± 2.13) kg / m2 respectively (P <0.05); the blood pressure was (103.06 ± 11.40) / (68.58 ± 8.12) mm Hg and (95.37 ± 5.40) / (60.26 ± 4.04) mm Hg (P <0.05). Conclusions The infection of intestinal Ad-36 in pre-school children is related to the rise of body mass index and the increase of diastolic blood pressure, suggesting that Ad-36 infection may have some influence on the occurrence of obesity.