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目的 探讨血清瘦素和可溶性瘦素受体水平与代谢综合征的关系。方法 检测 1 1 0例住院健康体检者、2型糖尿病 (2 DM)及合并冠心病患者血清瘦素 (Lp)、可溶性瘦素受体 (sLR)水平并分析其与血糖 (BG)、总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、载脂蛋白ApoA、ApoB、ApoA/B、胰岛素(Ins)、C 肽 (C p)、HOMA胰岛素抵抗指数 (HOMA IR)、体质指数 (BMI)、腰臀比 (WHR)等临床指标的相关性。 结果 疾病组Lp水平明显高于对照组 ,sLR水平明显降低 ,有极显著性差异 (P <0 .0 0 1 )。相关分析显示Lp与BMI、Ins、C p、HOMA IR、TC、ApoB呈正相关 ,与sLR、ApoA、ApoA/B呈负相关 ;sLR与Lp、C p、BMI呈负相关 ,与ApoA/B呈正相关 ,有显著性差异或极显著性差异 (P <0 .0 5或 0 .0 0 1 ) ,与Ins、HOMA IR、TC、ApoB、ApoA无显著性差异(P >0 .0 5 )。结论 疾病组Lp升高、sLR降低 ,提示Lp抵抗可能是 2 DM及冠心病的重要发病因素。Lp、sLR水平与BMI、血脂、Ins、C p、HOMA IR等临床指标相关性分析显示 ,代谢综合征的发生可能与Lp、sLR的变化有关 ,其因果关系尚需进一步探讨
Objective To investigate the relationship between serum leptin and soluble leptin receptor and metabolic syndrome. Methods The levels of serum leptin (Lp) and soluble leptin receptor (sLR) in 110 healthy inpatients with type 2 diabetes mellitus (DM) and patients with coronary heart disease (CHD) were detected and compared with those of blood glucose (BG), total cholesterol TC, TG, HDL, LDL, apolipoprotein ApoA, ApoB, ApoA / B, Ins, C peptide HOMA insulin resistance index (HOMA IR), body mass index (BMI), waist-to-hip ratio (WHR) and other clinical indicators. Results The Lp level in the disease group was significantly higher than that in the control group, and the sLR level was significantly lower (P <0.01). Correlation analysis showed that Lp was positively correlated with BMI, Ins, C p, HOMA IR, TC, ApoB and negatively correlated with sLR, ApoA and ApoA / B; sLR was negatively correlated with Lp, C p, There was no significant difference between the two groups (P <0.05 or 0.01), but not with Ins, HOMA IR, TC, ApoB and ApoA (P> 0.05). Conclusion Lp increased and sLR decreased in disease group, suggesting that Lp resistance may be an important risk factor of 2 DM and coronary heart disease. Lp, sLR levels and BMI, blood lipids, Ins, C p, HOMA IR and other clinical indicators of correlation analysis showed that the occurrence of metabolic syndrome may be related to changes in Lp, sLR, the causal relationship needs further study