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目的：：探讨了胃癌患者手术治疗前后血清IGF-I、HCY和CA724水平的变化及临床意义。方法：应用放射免疫分析法和酶联法对31例胃癌患者进行了手术治疗前后血清IGF-I、HCY和CA724水平检测，并与35名正常健康人作比较。结果：胃癌患者在手术治疗前血清IGF-I、HCY和CA724水平均非常显著地高于正常人组（p＜0.01），经手术治疗6个月后则与正常人比较无显著性差异（p＞0.05），且血清IGF-I水平与HCY、CA724水平呈显著正相关（r=0.5926,0.6021， p＜0.01）。结论：检测胃癌患者治疗前后血清IGF-I、HCY和CA724水平的变化对观察病情和预后判定均有重要的临床价值。“,”Objective To explore The clinical Significance of measurement of Changes of Serum IGF-I、HCY and CA724 levels after operation in patients With gastric cancer. Methods:Serum IGF-I、CA724 (With RIA), and Serum HCY (With ELISA) levels were determined in 31 patients With gastric cancer both before and after operation as wel as in 35 controls. Results Before operation, the Serum IGF-I、HCY and CA724 levels were Significantly higher in the patients than those in the Controls(p0.05).Serum IGF-I levels were positively correlated With Serum HCY 、CA724 levels(r=0.5926、0.6021, p<0.01).Conclusions Detection of Serum IGF-I、HCY and CA724 levels after operation might be of prognostic in protance in patients With gastric cancer.