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目的:探讨西宁地区妊娠期肝内胆汁淤积症(intrahepatic cholestasis of preplancy,ICP)患者脐血流比值及围产儿预后的关系。方法:选择2012年10月—2013年5月在我院未临产的以剖宫产结束妊娠的ICP孕产妇30例为观察组,以社会因素剖宫产终止妊娠孕妇30例为对照组,两组孕妇均无其他妊娠合并症,且其年龄、身高、体重比较均无明显差异。观察记录两组产前彩超检查情况,记录脐血流收缩期与舒张期的比值(S/D值)、阻力指数(RI值)、波动指数(PI值)。记录两组羊水胎粪污染,胎儿窘迫,早产,新生儿窒息,新生儿吸入性肺炎的情况。结果:观察组的S/D和PI平均值均高于对照组(P<0.001);观察组的S/D和PI结果异常的围产儿预后不良发生率明显高于对照组(P<0.05和P<0.005)。结论:观察组患者应常规进行胎儿脐动脉血流阻力检测,以便及时处理,改善观察患者围产儿预后。
Objective: To investigate the relationship between cord blood flow ratio and perinatal outcome in patients with intrahepatic cholestasis of preplancy (ICP) during pregnancy in Xining. Methods: From October 2012 to May 2013, 30 pregnant women with cesarean section who did not give birth in our hospital were enrolled in this study. 30 pregnant women with cesarean termination of pregnancy were selected as the control group, There was no other pregnancy complications in the group of pregnant women, and there was no significant difference in their age, height and weight. Observe and record two groups of prenatal color Doppler ultrasound examination, recording umbilical blood flow systolic and diastolic ratio (S / D value), resistance index (RI value), volatility index (PI value). Record two groups of amniotic fluid meconium contamination, fetal distress, premature birth, neonatal asphyxia, neonatal aspiration pneumonia. Results: The mean S / D and PI in the observation group were significantly higher than those in the control group (P <0.001). The incidence of poor prognosis of perinatal children with abnormal S / D and PI findings in the observation group was significantly higher than that in the control group (P <0.05 and P <0.005). Conclusion: The observation group should routinely carry out the detection of fetal umbilical artery blood flow resistance in order to timely treatment to improve the prognosis of patients observed perinatal.