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目的以脂溶性药物丹皮酚为模型药物,制备载药传递体,评价其质量并进行小鼠经皮渗透体外研究。方法采用薄膜分散-超声法制备丹皮酚传递体;以改进的Franz扩散池进行体外小鼠经皮渗透实验,比较不同处方组成对丹皮酚经皮渗透的影响。结果丹皮酚传递体为乳白色、近透明的胶体溶液。脂质传递体、普通脂质体和丹皮酚水醇混悬液8h时的累积渗透率分别为81.22%、49.66%、42.22%。结论丹皮酚传递体制备工艺简单可行,所制传递体的粒径较小且均匀,并可促进丹皮酚的经皮转运。
OBJECTIVE To prepare the drug delivery system by paeonol, a lipid-soluble drug, and evaluate the quality of the drug delivery system in vitro. Methods Paeoniflorin mediator was prepared by membrane dispersion - ultrasonic method. The transdermal penetration of mice in vitro was evaluated by the improved Franz diffusion cell. The effects of different prescriptions on the transdermal permeation of paeonol were compared. Results Paeonol phenol transfer agent is milky white, nearly transparent colloidal solution. The cumulative permeabilities of the liposomes, liposomes and paeonol hydroquinolone suspension at 8h were 81.22%, 49.66% and 42.22%, respectively. Conclusion The preparation process of paeonol delivery is simple and feasible. The size of the delivery system is small and uniform, and the transdermal transport of paeonol can be promoted.