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目的探讨轮状病毒(RV)血症与其临床症状的关系。方法对2007年10月至2009年7月在安徽省立医院治疗的480例RV肠炎患儿,采用金标法和酶联免疫吸附(ELISA)方法,检测其血清RV抗原,并因此分为血清RV抗原阳性组及血清RV抗原阴性组,同时检测50名健康儿童血清RV抗原作为对照组,并分析血清RV抗原阳性与临床症状的关系。结果 RV肠炎患儿其血清RV抗原阳性率90%,血清RV抗原阳性组和血清RV抗原阴性组在腹泻的次数及脱水的严重程度上差异无统计学意义(P>0.05),血清RV抗原阳性组脏器损害的发生率明显高于RV抗原阴性组(P<0.05)。结论 RV感染患儿存在着RV病毒血症,年龄对血清病毒血症没有明显影响,病毒血症和腹泻严重程度无直接关系,但和肠道外脏器损害有关。
Objective To investigate the relationship between rotavirus (RV) and its clinical symptoms. Methods A total of 480 patients with RV enteritis treated in Anhui Provincial Hospital from October 2007 to July 2009 were tested for serum RV antigen by gold standard and enzyme-linked immunosorbent assay (ELISA) RV antigen positive group and serum RV antigen negative group. At the same time, serum RV antigen in 50 healthy children was detected as the control group, and the relationship between serum RV antigen positive and clinical symptoms was analyzed. Results The positive rate of serum RV antigen in children with RV enteritis was 90%. There was no significant difference in the frequency of diarrhea and the severity of dehydration between serum RV antigen positive group and serum RV antigen negative group (P> 0.05). Serum RV antigen positive The incidence of organ damage was significantly higher than RV negative group (P <0.05). Conclusion RV infection in children with RV viremia, age, no significant effect on serum viremia, viremia and the severity of diarrhea is not directly related, but with damage to the external organs of the intestine.