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目的观察针对性治疗老年高血压并发腔隙性脑梗死对患者血清Hcy、PAI-1水平的影响。方法选取2012年6月-2014年7月在该院就诊的115例老年高血压并发腔隙性脑梗死患者为观察组,同时选择同期入该院检查的健康体检者80例为健康组。对观察组进行降血压、降糖、降脂、改善脑循环等治疗,分别检测观察组治疗前后、健康组血清Hcy、PAI-1水平。结果观察组治疗前血清Hcy、PAI-1水平均高于健康组,且治疗后观察组血清Hcy、PAI-1水平均低于治疗前,差异均有统计学意义(P<0.05)。治疗后观察组血清Hcy、PAI-1水平较健康组差异无统计学意义(P>0.05)。结论针对性治疗老年高血压并发腔隙性脑梗死能有效地降低患者血清Hcy、PAI-1水平。
Objective To observe the effect of targeted therapy on the serum levels of Hcy and PAI-1 in patients with senile hypertension and lacunar infarction. Methods A total of 115 elderly patients with hypertension complicated with lacunar infarction who were admitted to our hospital from June 2012 to July 2014 were selected as the observation group. Meanwhile, 80 healthy subjects who were admitted to the hospital during the same period were selected as the healthy group. Hypotension, hypoglycemic, lipid-lowering and cerebral circulation improvement were observed in the observation group. Serum levels of Hcy and PAI-1 in the observation group were measured before and after treatment. Results The levels of Hcy and PAI-1 in the observation group before treatment were significantly higher than those in the healthy group. The levels of Hcy and PAI-1 in the observation group were lower than those before treatment (P <0.05). After treatment, serum Hcy and PAI-1 levels in the observation group were not significantly different from those in the healthy group (P> 0.05). Conclusion Targeted treatment of senile hypertension with lacunar infarction can effectively reduce the serum levels of Hcy and PAI-1.