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传统肖顿-鲍曼反应需要使用环境非友好的脂肪酰氯以及低沸点有机溶剂,且会生成氯化钠副产物,该文主要对肖顿-鲍曼反应进行改进。在甲醇钠(SM)催化下以月桂酸甲酯(ML)与甘氨酸钠(SG)为原料在甘油中缩合合成N-月桂酰基甘氨酸钠(SLG),并采用FTIR和1HNMR证实所得产物为目标分子SLG。考察了反应溶剂种类、催化剂种类、ML与SG的摩尔比、催化剂用量、反应时间和反应温度对收率的影响,得到在甘油为溶剂和SM为催化剂时,n(ML)∶n(SG)∶n(SM)=1.0∶2.5∶0.02,于135℃反应3.5 h后SLG的收率达78.7%。与传统肖顿-鲍曼反应相比,改进后反应环境友好性增强,不使用脂肪酰氯,不生成氯化钠副产物以及无需低沸点有机溶剂。
The traditional Shotau-Bowman reaction requires the use of environmentally unfriendly fatty acid chlorides as well as low-boiling organic solvents and the formation of sodium chloride byproducts. This paper mainly improves the Schotten-Bowman reaction. Sodium lauroylglycinate (SLG) was synthesized by the condensation of glycerol with methyl laurate (ML) and sodium glycinate (SG) catalyzed by sodium methylate (SM) and confirmed by FTIR and 1HNMR that the target product SLG. The effects of reaction solvent type, catalyst type, molar ratio of ML to SG, catalyst dosage, reaction time and reaction temperature on the yield were investigated. When glycerol was used as solvent and SM as catalyst, the molar ratio of n (ML) : SM (SM) = 1.0: 2.5: 0.02, the yield of SLG reached 78.7% after reacting at 135 ℃ for 3.5 h. Compared with the traditional Schotten-Bowman reaction, the improved reaction environment-friendliness is enhanced without using fatty acid chloride, no sodium chloride byproduct formation and no need of low-boiling organic solvents.